Cephalexin is a first-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Dosage:
The usual adult dose is 250-500mg every 6-12 hours, while for children the dose is based on weight.
Dosage adjustments may be necessary in patients with liver or renal impairment.
In pregnancy, cephalexin is generally considered safe but should be used with caution, while in lactation, it is excreted in breast milk but has not been shown to cause harm to the nursing infant.
Indications:
Cephalexin is used to treat infections caused by susceptible organisms, including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and bone infections.
Advice to the patient:
Complete the full course of antibiotics as prescribed.
Take with food to reduce stomach upset.
Do not take antacids containing aluminum or magnesium within 2 hours of taking cephalexin.
Administration:
Cephalexin is taken orally, with or without food.
Tablets should be swallowed whole and not chewed or crushed.
Pharmacokinetics:
Cephalexin is well-absorbed orally and reaches peak blood levels within 1-2 hours.
It is excreted primarily unchanged in the urine and has a half-life of approximately 1 hour.
Pharmacology:
Cephalexin inhibits bacterial cell wall synthesis by binding to specific penicillin-binding proteins, resulting in bacterial cell death.
Interactions:
Cephalexin may interact with other drugs that affect the kidneys, including diuretics and non-steroidal anti-inflammatory drugs (NSAIDs).
Adverse effects:
Adverse effects of cephalexin include gastrointestinal upset, allergic reactions, and diarrhea.
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