Oxacillin is a type of antibiotic in the penicillin class, commonly used to treat bacterial infections caused by susceptible organisms. Here is some information on the drug from Medscape and UpToDate:
Dosage:
For adults, the recommended dose of oxacillin is 250-500 mg every 4-6 hours, up to a maximum of 12 g per day. For children, the recommended dose is 25-50 mg/kg/day, divided into 4-6 doses.
Dosage in liver and renal impairment:
In patients with severe renal impairment, the dose of oxacillin may need to be reduced, and in those with hepatic impairment, the drug should be used with caution and under close monitoring.
Pregnancy and lactation:
Oxacillin is generally considered safe for use during pregnancy and lactation. However, it should be used with caution and only if the potential benefits outweigh the risks to the fetus or infant.
Risk factors and indications:
Oxacillin is indicated for the treatment of infections caused by susceptible organisms, such as skin and soft tissue infections, respiratory tract infections, and infections caused by Staphylococcus aureus.
Advice to patient:
Patients should take oxacillin as directed by their healthcare provider and complete the full course of treatment, even if symptoms improve. They should also inform their doctor if they experience any side effects, such as diarrhea, rash, or allergic reactions.
Administration:
Oxacillin can be administered orally or intravenously, depending on the severity of the infection and the patient's condition.
Pharmacokinetics:
Oxacillin is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. The drug is mainly excreted in the urine and has a half-life of approximately one hour.
Interactions:
Oxacillin may interact with other medications, such as probenecid and warfarin, and caution should be used when administering it concurrently with these drugs.
Adverse effects:
The most common side effects of oxacillin include diarrhea, nausea, vomiting, and rash. Rare but serious adverse effects include anaphylaxis, severe skin reactions, and liver dysfunction.
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