Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and fever. Here's the information you asked for:
Dosage:
For adults, the usual oral dose is 100-200 mg every 12 hours.
For children over 12 years of age, the usual dose is 100 mg every 12 hours.
The maximum daily dose for adults is 300-400 mg, and for children, it is 200 mg.
The dosage may vary depending on the condition being treated, the patient's age, and their medical history.
Dosage in liver and renal impairment:
Flurbiprofen is contraindicated in patients with severe hepatic impairment or severe renal impairment.
In patients with mild to moderate liver impairment or renal impairment, the dosage should be reduced. Consult with a doctor for the appropriate dosage adjustment.
Pregnancy and lactation:
Flurbiprofen is not recommended for use during pregnancy, especially during the third trimester, as it may harm the unborn baby.
It is not recommended for use during breastfeeding as it passes into breast milk.
Risk factors:
Flurbiprofen should be used with caution in patients with a history of gastrointestinal bleeding, peptic ulcer disease, or other bleeding disorders.
It may increase the risk of cardiovascular events such as heart attack or stroke, especially with long-term use or in patients with existing cardiovascular disease.
Flurbiprofen should not be used in patients with aspirin-sensitive asthma or patients with a history of allergic reactions to NSAIDs.
Indications:
Flurbiprofen is used to relieve pain, inflammation, and fever associated with conditions such as osteoarthritis, rheumatoid arthritis, and menstrual cramps.
Advice to patients:
Take Flurbiprofen with food or milk to avoid stomach upset.
Do not take more than the recommended dose or use for longer than prescribed.
Do not use Flurbiprofen if you have a history of aspirin-sensitive asthma or allergic reactions to NSAIDs.
Inform your doctor if you have a history of gastrointestinal bleeding, peptic ulcer disease, or other bleeding disorders.
Administration:
Flurbiprofen is available in tablet form and should be taken orally.
The tablets should be swallowed whole with water and should not be chewed, crushed, or broken.
Pharmacokinetics:
Flurbiprofen is rapidly absorbed after oral administration and reaches peak plasma concentration within 1-2 hours.
It is metabolized in the liver and excreted in the urine and feces.
The half-life of Flurbiprofen is approximately 4-6 hours.
Interactions:
Flurbiprofen may interact with other medications such as anticoagulants, aspirin, and other NSAIDs.
Inform your doctor if you are taking any other medications, including over-the-counter drugs, herbal supplements, or vitamins.
Adverse effects:
The common side effects of Flurbiprofen include stomach upset, nausea, vomiting, diarrhea, constipation, and headache.
It may also cause dizziness, drowsiness, and blurred vision.
Serious side effects may include gastrointestinal bleeding, liver damage, and kidney damage.
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