Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its analgesic, anti-inflammatory, and antipyretic properties. It is available in both prescription and over-the-counter (OTC) formulations. Here are some important considerations related to ibuprofen:
Dosage:
For adults and children 12 years and older: the usual dose is 200-400 mg every 4-6 hours as needed, up to a maximum of 1200 mg per day.
For children younger than 12 years: the dose is based on the child's weight. The usual dose is 5-10 mg/kg every 6-8 hours, up to a maximum of 40 mg/kg per day.
Dosage in liver and renal impairment:
Ibuprofen should be used with caution in patients with liver or renal impairment. Dosing adjustments may be necessary in these patients.
Pregnancy and lactation:
Ibuprofen is generally not recommended during pregnancy, especially during the third trimester, due to the risk of premature closure of the ductus arteriosus in the fetus.
Ibuprofen is excreted in breast milk and should be used with caution in nursing mothers.
Risk factors:
Patients with a history of gastrointestinal bleeding, peptic ulcer disease, or kidney problems should use ibuprofen with caution.
Patients with a history of aspirin or other NSAID allergy should avoid ibuprofen.
Indications:
Ibuprofen is indicated for the relief of mild to moderate pain, inflammation, and fever.
Advice to patient:
Patients should take ibuprofen with food or milk to reduce the risk of gastrointestinal side effects.
Patients should avoid taking ibuprofen with other NSAIDs, including aspirin, as this may increase the risk of adverse effects.
Patients should inform their healthcare provider if they have any liver or renal problems, are pregnant or breastfeeding, or have any other medical conditions.
Administration:
Ibuprofen is available in various formulations, including tablets, capsules, liquid, and topical gels or creams.
Patients should follow the dosing instructions on the label or as directed by their healthcare provider.
Ibuprofen should not be taken for more than 10 days without consulting a healthcare provider.
Pharmacokinetics:
Ibuprofen is rapidly absorbed after oral administration and has a half-life of 2-4 hours.
Ibuprofen is metabolized in the liver and excreted in the urine.
Interactions:
Ibuprofen may interact with other medications, including anticoagulants, corticosteroids, and selective serotonin reuptake inhibitors (SSRIs).
Patients should inform their healthcare provider of all medications they are taking before starting ibuprofen.
Adverse effects:
Common side effects of ibuprofen include nausea, stomach pain, and heartburn.
Serious adverse effects, including gastrointestinal bleeding, liver or kidney problems, and allergic reactions, may occur in some patients.
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