Dicloxacillin is a narrow-spectrum antibiotic that belongs to the penicillin class of drugs. It is used to treat bacterial infections caused by susceptible organisms. Here is information on dicloxacillin from various sources:
Risk Factors:
Hypersensitivity to penicillin or any other component of dicloxacillin is a contraindication to its use. Patients with a history of liver disease or renal impairment should use dicloxacillin with caution.
Indications:
Dicloxacillin is used to treat bacterial infections such as skin and soft tissue infections, bone infections, and respiratory tract infections.
Dosage:
Adult dosage (from Medscape): 250-500mg orally every six hours or 500mg-1g orally every eight hours for severe infections.
Children dosage (from Medscape): 12.5-25mg/kg/day orally in divided doses every six hours or 25-50mg/kg/day orally in divided doses every eight hours for severe infections.
Dosage in liver and renal impairment:
Patients with liver or renal impairment may require a lower dose of dicloxacillin due to decreased clearance.
Pregnancy and lactation:
Dicloxacillin is generally considered safe to use during pregnancy and lactation. However, it should be used with caution and only when necessary.
Advice to patient:
Patients should take dicloxacillin exactly as prescribed by their healthcare provider, even if they feel better before the course of treatment is complete. They should not skip doses or stop taking the medication without first consulting their healthcare provider. Patients should also avoid consuming alcohol while taking dicloxacillin.
Administration:
Dicloxacillin is usually taken orally, with or without food. The capsules should be swallowed whole, without crushing or chewing.
Pharmacokinetics:
Dicloxacillin is rapidly absorbed after oral administration and has a half-life of approximately one hour. It is excreted primarily in the urine.
Interactions:
Dicloxacillin may interact with other medications, such as warfarin, which can increase the risk of bleeding. It may also decrease the effectiveness of hormonal contraceptives.
Adverse effects:
Common adverse effects of dicloxacillin include nausea, vomiting, diarrhea, and skin rash. Rare but serious adverse effects include anaphylaxis and liver toxicity.
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