Risk Factors:
Flucloxacillin is contraindicated in patients with a known hypersensitivity to penicillin or any of its components. Patients with liver disease or renal impairment should use flucloxacillin with caution.
Indications:
Flucloxacillin is used to treat bacterial infections such as skin and soft tissue infections, bone infections, and respiratory tract infections.
Dosage:
Adult dosage: 250-500mg orally every six hours or 1-2g orally every six hours for severe infections.
Children dosage: 25-50mg/kg/day orally in divided doses every six to eight hours for severe infections.
Dosage in liver and renal impairment:
Patients with liver or renal impairment may require a lower dose of flucloxacillin due to decreased clearance.
Pregnancy and lactation:
Flucloxacillin is generally considered safe to use during pregnancy and lactation. However, it should be used with caution and only when necessary.
Advice to patient:
Patients should take flucloxacillin exactly as prescribed by their healthcare provider, even if they feel better before the course of treatment is complete. They should not skip doses or stop taking the medication without first consulting their healthcare provider. Patients should also avoid consuming alcohol while taking flucloxacillin.
Administration:
Flucloxacillin is usually taken orally, with or without food. The capsules should be swallowed whole, without crushing or chewing.
Pharmacokinetics:
Flucloxacillin is rapidly absorbed after oral administration and has a half-life of approximately one hour. It is excreted primarily in the urine.
Interactions:
Flucloxacillin may interact with other medications, such as warfarin, which can increase the risk of bleeding. It may also decrease the effectiveness of hormonal contraceptives.
Adverse effects:
Common adverse effects of flucloxacillin include nausea, vomiting, diarrhea, and skin rash. Rare but serious adverse effects include anaphylaxis and liver toxicity.
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