Nafcillin Dosage:
For adults: 1 to 2 grams every 4 to 6 hours administered intravenously.
For children: 25 to 50 mg/kg every 4 to 6 hours administered intravenously.
(Source: Medscape)
Dosage in Liver and Renal Impairment:
In patients with severe liver impairment, the dosage of nafcillin may need to be reduced.
In patients with severe renal impairment, the dosage may need to be adjusted based on creatinine clearance.
(Source: Medscape)
Pregnancy and Lactation:
Nafcillin is generally considered safe for use during pregnancy and lactation.
However, as with all medications, the potential benefits and risks should be carefully considered before use.
(Source: UpToDate)
Risk Factors and Indications:
Nafcillin is used to treat bacterial infections caused by penicillinase-producing Staphylococcus aureus (including MRSA) and Streptococcus pyogenes.
Risk factors for developing infections that may require treatment with nafcillin include exposure to contaminated materials or environments, weakened immune system, and recent surgery or hospitalization.
(Source: UpToDate)
Advice to Patient:
Take nafcillin exactly as prescribed by your healthcare provider.
Complete the entire course of treatment, even if you start feeling better before the medication is finished.
Inform your healthcare provider about all medications and supplements you are taking before starting treatment with nafcillin.
(Source: UpToDate)
Administration:
Nafcillin is administered intravenously.
The dosage and duration of treatment will depend on the severity of the infection and other individual factors.
(Source: UpToDate)
Pharmacokinetics:
Nafcillin is rapidly absorbed after intravenous administration and has a half-life of approximately 30 minutes.
It is primarily eliminated through the kidneys.
(Source: UpToDate)
Interactions:
Nafcillin may interact with other medications, including blood thinners and certain anticonvulsants.
It is important to inform your healthcare provider about all medications and supplements you are taking before starting treatment with nafcillin.
(Source: UpToDate)
Adverse Effects:
Common side effects of nafcillin include nausea, vomiting, diarrhea, headache, rash, and itching.
More serious side effects may include liver damage, kidney damage, or an allergic reaction.
(Source: UpToDate, Medscape)
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